The inaccessibility of the terrain between Santa Catarina and San Andres, the two foremost communities of the Huichol Sierra shown below, forces the people to make the 264 km detour through Huejuquilla when visiting each other.
Huejuquilla is not only a transit point for he indigenous inhabitants of the region, but also their gateway to the rest of the country and specifically Wirikuta, in the northern state of San Luis Potosi, where the peyote grows and the gods are met on the Cerro Quemado.

Since hunting is prohibited in their mountainous hold-outs, the Huichol hunters come from the interior to Huejuquilla, to hunt in Jalisco state.There they camp at the Huichol Center's campsite, from where they stage daily hunting parties further east. Once they've gotten enough deer meat for their ritual offerings, they can return home and prepare the ceremonies in which the game is used.

Along the road between San Andres and Santa Catarina are numerous small hamlets and villages with their own xiriki (family temples) or tupika (bigger communal temples).

Individual travellers coming from the interior in function of their oficial indigenous mandate, or on their way back to the Sierra, are lodged at an appartment, in the Blue House, or in the Huichol Indigenous Center, which besides shelter also provides a library and a meeting room for its guests, some of whom come from overseas to get to know the Huichol people in person and study their customs and beliefs for religious, anthropological, theatrical and other purposes.